Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease.

Nidhi DwivediShixin TaoAbeda JamadarSonali SinhaChristianna HowardDarren P WallaceTimothy A FieldsAndrew LeaskJames P CalvetReena Rao

Published in: Journal of the American Society of Nephrology : JASN (2020)

Our results demonstrate a novel mechanism by which cystic epithelial cells stimulate myofibroblasts in the pericystic microenvironment, leading to fibrosis in ADPKD. The V2R-YAP-CCN2 cell signaling pathway may present a potential therapeutic target for fibrosis in ADPKD.

Keyphrases

polycystic kidney disease
signaling pathway
stem cells
cell therapy
epithelial mesenchymal transition
pi k akt
liver fibrosis
oxidative stress
cell proliferation