Distinct transcriptional signatures in purified circulating immune cells drive heterogeneity in disease location in IBD.

Bram Verstockt Sare VerstocktJonathan CremerJoão SabinoMarc FerranteSeverine VermeirePadhmanand Sudhakar

Published in: BMJ open gastroenterology (2023)

Transcriptomic profiling of circulating CD4 T-cells in patients with IBD demonstrated marked molecular differences between the IBD-spectrum extremities (UC and predominantly ileal CD, sandwiching colonic CD), which could help in prioritising particular drug targets for IBD subtypes.

Keyphrases

ulcerative colitis
single cell
gene expression
nk cells
emergency department
oxidative stress
dna methylation
heat shock
single molecule
electronic health record
heat shock protein