Neonatal Isolation Increases the Susceptibility to Learned Helplessness through the Aberrant Neuronal Activity in the Ventral Pallidum of Rats.

Hironori Kobayashi Manabu Fuchikami Kenichi Oga Tatsuhiro Miyagi Sho Fujita Satoshi Fujita Satoshi Okada Yasumasa Okamoto Shigeru Morinobu

Published in: Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology (2024)

: These findings suggest that the aberrant VP neuronal activity due to environmental deprivation early in life leads to pessimistic associative and implicit learning. Modulating VP neuronal activity could be a novel therapeutic and preventive strategy for the patients with this specific pathophysiology.

Keyphrases

cerebral ischemia
spinal cord
signaling pathway
risk assessment
climate change
disease virus
life cycle