Adjunctive tianeptine treatment for bipolar disorder: A 24-week randomized, placebo-controlled, maintenance trial.

Márcia Kauer-Sant'AnnaBenicio N FreyAdam FijtmanAna C Loredo-SouzaAroldo A DargélBianca PfaffensellerBianca Wollenhaupt-AguiarFernando K GazalleGabriela D ColpoIves C PassosJoana BückerJúlio C WalzKaren JansenMendes CeresérKelen P Bürke BridiLisiane Dos Santos SóriaMaurício KunzMichele PinhoNatália S KapczinskiPedro D GoiPedro Vs MagalhãesRamiro ReckziegelRenan K BurqueTaiane de Azevedo CardosoFlavio Kapczinski

Published in: Journal of psychopharmacology (Oxford, England) (2019)

Tianeptine was not more effective than placebo in the maintenance treatment of bipolar depression. There is preliminary evidence suggesting a pro-cognitive effect of tianeptine in working memory compared to placebo.

Keyphrases

placebo controlled
double blind
phase iii
working memory
bipolar disorder
phase ii
clinical trial
open label
study protocol
depressive symptoms
squamous cell carcinoma
physical activity
radiation therapy
anti inflammatory