Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers.
Zhengbo HuRamya ViswanathanHui ChengJianghong ChenXinping YangAngel HuynhPaul ClavijoYi AnYvette RobbinsChristopher SilvinClint AllenPinar OrmanogluScott MartinShaleeka CorneliusAnthony SalehZhong ChenCarter Van WaesEthan L MorganPublished in: Molecular cancer research : MCR (2022)
Inhibiting WEE1 and IKK-RELA crosstalk could potentially enhance the effects of therapies mediated by TNFα with less systemic immune suppression and toxicity than observed with direct interruption of IKK-NF-κB/RELA signaling.