Myeloid-derived suppressor cells at diagnosis may discriminate between benign and malignant ovarian tumors.

An CoosemansThaïs BaertJolien CeustersPieter BusschaertChiara LandolfoTina VerschuereAnne-Sophie Van RompuyAdriaan VandersticheleWouter FroymanPatrick NevenBen Van CalsterIgnace VergoteDirk Timmerman

Published in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2020)

Our immune profile in blood suggests an involvement of innate immunosuppression driven by myeloid-derived suppressor cells in the development of ovarian cancer. This finding could contribute to clinical management of patients and in selection of immunotherapy.

Keyphrases

induced apoptosis
cell cycle arrest
immune response
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell proliferation