HLA-B27 alters BMP/TGFβ signalling in Drosophila, revealing putative pathogenic mechanism for spondyloarthritis.

Benjamin GrandonAurore Rincheval-ArnoldNadège JahJean-Marc CorsiLuiza M AraujoSimon GlatignyErwann PrevostDelphine RocheGilles ChiocchiaIsabelle GuénalSébastien GaumerMaxime Breban

Published in: Annals of the rheumatic diseases (2019)

Antagonistic interaction of HLA-B27 with ALK2, which exerts inhibitory functions on the TGFβ/BMP signalling pathway at the cross-road between inflammation and ossification, could adequately explain SpA development.

Keyphrases

transforming growth factor
mesenchymal stem cells
bone regeneration
oxidative stress
ankylosing spondylitis
epithelial mesenchymal transition
disease activity
rheumatoid arthritis
bone marrow
epidermal growth factor receptor