Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.
Darius Ebrahimi-FakhariJulian Emanuel AlecuMarvin ZieglerGregory GeiselCatherine JordanAngelica D'AmoreRebecca C YehShyam K AkulaAfshin SaffariSanjay P PrabhuMustafa SahinEdward Yangnull nullPublished in: Neurology (2021)
Our findings define the MRI spectrum of AP-4-HSP, providing opportunities for early diagnosis, identification of individuals at risk for complications, and a window into the role of the AP-4 complex in brain development and neurodegeneration.
Keyphrases
- contrast enhanced
- resting state
- magnetic resonance imaging
- white matter
- transcription factor
- diffusion weighted imaging
- functional connectivity
- heat shock protein
- cerebral ischemia
- computed tomography
- risk factors
- cerebral palsy
- magnetic resonance
- heat stress
- amino acid
- small molecule
- heat shock
- upper limb
- binding protein
- botulinum toxin
- brain injury