Antibodies against type I interferon: detection and association with severe clinical outcome in COVID-19 patients.
David GoncalvesMehdi MezidiPaul BastardMagali PerretKahina SakerNicole FabienRemi PescarmonaChristine LombardThierry WalzerJean Laurent CasanovaAlexandre BelotJean-Christophe RichardSophie Touillet-AssantPublished in: Clinical & translational immunology (2021)
We reported that 18% of critically ill COVID-19 patients were positive for IFN-I auto-Abs, whereas all mild COVID-19 patients were negative, confirming that the presence of these antibodies is associated with a higher risk of developing a critical COVID-19 form.