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Visible-light-mediated intramolecular radical cyclization of α-brominated amide-tethered alkylidenecyclopropanes.

Ben MaoXiao-Yu ZhangYin WeiMin Shi
Published in: Chemical communications (Cambridge, England) (2022)
A ring-opening/cyclization cascade reaction of α-brominated amide-tethered alkylidenecyclopropanes in the presence of photocatalyst 4CzIPN under visible-light irradiation was developed to afford polycyclic benzazepine derivatives in good yields with broad substrate scope and good functional tolerance. A plausible mechanism involving a halogen atom transfer (XAT) process and a radical chain process is proposed for this reaction. This study provides a concise and practical strategy for the synthesis of benzazepine derivatives.
Keyphrases
  • visible light
  • electron transfer
  • molecular dynamics
  • structure activity relationship
  • radiation induced
  • radiation therapy