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Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia.

Mirella T S BarboniNoémi SzéllZoltán SohajdaTamás Fehér
Published in: Investigative ophthalmology & visual science (2024)
L/M-cone abnormalities due to ARR3 gene mutation is currently claimed to underlie the pathological eye growth in MYP-26. Our results suggest that malfunction of the melanopsin system of intrinsically photosensitive retinal ganglion cells (ipRGCs) is specific to patients with symptomatic MYP-26, and may therefore play an additional role in the pathological eye growth of MYP-26.
Keyphrases
  • early onset
  • late onset
  • induced apoptosis
  • cell cycle arrest
  • optic nerve
  • optical coherence tomography