Association between Serum Soluble Urokinase-Type Plasminogen Activator Receptor Level and Arterial Stiffness in Chronic Hemodialysis Patients.
Wei-Chen LinTsung-Jui WuChih-Hsien WangYi-Jen HsiehBang-Gee HsuPublished in: Journal of personalized medicine (2023)
Cardiovascular diseases (CVDs) remain a significant cause of death in hemodialysis (HD) patients. To explore their associations, we examine the role of soluble urokinase-type plasminogen activator receptor (suPAR) in arterial stiffness in chronic HD patients. From June to August 2020, we recruited 135 chronic HD patients. The arterial stiffness group included patients with a carotid-femoral pulse-wave velocity (cfPWV) of >10 m/s. Fifty-five HD patients (40.7%) were in the arterial stiffness group. They had a higher prevalence of diabetes ( p = 0.001) and hypertension ( p = 0.039), were older ( p = 0.007) and had higher aortic systolic blood pressure ( p = 0.034), brachial systolic blood pressure ( p = 0.025), glucose ( p = 0.019), C-reactive protein ( p = 0.039), and AIx75 ( p = 0.003) and suPAR ( p < 0.001) levels than the control group. After we performed multivariable logistic regression analysis, except age and glucose, serum suPAR (odds ratio [OR]: 2.05; 95% confidence interval [CI]: 1.48-2.70, p < 0.001) was independently associated with arterial stiffness in chronic HD patients. In the multivariable linear regression analysis, suPAR positively correlated with cfPWV (β = 0.475, p < 0.001) and could serve as a biomarker for arterial stiffness development in patients undergoing HD.
Keyphrases
- blood pressure
- end stage renal disease
- chronic kidney disease
- ejection fraction
- cardiovascular disease
- newly diagnosed
- peritoneal dialysis
- patients undergoing
- left ventricular
- prognostic factors
- heart failure
- physical activity
- skeletal muscle
- adipose tissue
- heart rate
- blood glucose
- hypertensive patients
- aortic valve
- patient reported
- insulin resistance
- pulmonary arterial hypertension
- cardiovascular events
- weight loss
- middle aged