Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer.

Sergio Pedraza-ArévaloDaniel Hormaechea-AgullaEnrique Gómez-GómezMaría J RequenaLuke A SelthManuel D GaheteJusto P CastañoRaul Miguel Luque

Published in: The Prostate (2017)

Altogether, our results indicate that SSTR1 is overexpressed in PCa, where it can exert a relevant pathophysiological role by decreasing cell-proliferation and PSA secretion. Therefore, sst1, possibly in combination with miR-24, could be used as a novel tool to explore therapeutic targets in PCa.

Keyphrases

prostate cancer
cell proliferation
radical prostatectomy
cell cycle
long non coding rna
pi k akt
long noncoding rna
binding protein
signaling pathway