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Cell-Specific Dysregulation of Iron and Oxygen Homeostasis as a Novel Pathophysiology in PSP.

Seojin LeeIván Martínez-ValbuenaCarlos E de AndreaMaria Villalba-EsparzaSuganthini IlaalaganBlas CoutoNaomi P VisanjiAnthony E LangGábor G Kovács
Published in: Annals of neurology (2022)
We present novel aspects of PSP pathophysiology highlighting an overlap with NBIA pathways. Our findings reveal potential novel targets for therapy development and have implications beyond PSP for other iron-associated neurodegenerative diseases. ANN NEUROL 2022.
Keyphrases
  • single cell
  • iron deficiency
  • cell therapy
  • genome wide
  • stem cells
  • human health
  • mesenchymal stem cells
  • dna methylation