The Association of Proton Pump Inhibitors and QT Interval Prolongation in Critically Ill Patients.

Weiguo FanHualong LiuYang ShenKui Hong

Published in: Cardiovascular drugs and therapy (2023)

In ICU patients, the association between PPI prescription and increased risk of QT interval prolongation was independent of known QT-prolonging factors; pantoprazole and lansoprazole had a higher risk compared with omeprazole. The combination of PPIs and other QT-prolonging drugs should be avoided.

Keyphrases

drug induced
end stage renal disease
chronic kidney disease
newly diagnosed
intensive care unit
peritoneal dialysis
prognostic factors
small molecule