A Robust HPLC Approach for Quantitation of Camptothecin in Mesoporous Silica Nanoparticles Matrix and in the Presence of Its Degradation Products.

Richa R Dave Neel Savaliya Ashish Dobariya Rashmin B Patel Mrunali R Patel

Published in: Journal of AOAC International (2024)

Stability-indicating HPLC method was found to be specific and suitable for routine analysis of camptothecin. The absence of any interference from excipients was confirmed by forced degradation studies.

Keyphrases

ms ms
high performance liquid chromatography
simultaneous determination
solid phase extraction
liquid chromatography tandem mass spectrometry
tandem mass spectrometry
mass spectrometry
liquid chromatography
case control
high resolution