DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-κB and TGF-β/Smad signalling pathway.

J LinB LiQ XuY S LiuY L KangX WangY WangY LeiY L BaiX M LiJie Zhou

Published in: Journal of endocrinological investigation (2023)

This study proved that sPA presents a risk factor for kidney injuries and DACH1 might serve as a protective target against renal function deterioration in diabetic patients.

Keyphrases

toll like receptor
high glucose
transforming growth factor
nuclear factor
signaling pathway
inflammatory response
epithelial mesenchymal transition
immune response
diabetic rats
lps induced
oxidative stress
endothelial cells
pi k akt
drug induced