Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease.
Takara L StanleyLindsay T FourmanLai Ping WongRuslan SadreyevJames M BillingsleyMeghan N FeldpauschIsabel ZhengChelsea S PanAutumn BoutinHang LeeKathleen E CoreyMartin TorrianiDavid E KleinerRaymond T ChungColleen M HadiganSteven K GrinspoonPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Long-term treatment with a GHRH analog reduced markers of T-cell and monocyte/macrophage activity, suggesting that augmentation of the GH axis may ameliorate immune activation in an HIV population with metabolic dysregulation, systemic and end organ inflammation. Clinical Trials Registration. NCT02196831.