We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined multigene signature including APOD, DCN, and LUM. This cell population has previously been labeled as consisting of inflammatory cancer-associated fibroblasts (iCAFs). The same signature characterizes naturally occurring fibro-adipogenic progenitors (FAPs) as well as stromal cells abundant in normal adipose tissue. Our analysis of human gene expression databases provides evidence that adipose stromal cells (ASCs) are recruited by tumors and undergo differentiation into CAFs during cancer progression to invasive and chemotherapy-resistant stages.
Keyphrases
- adipose tissue
- gene expression
- single cell
- cell therapy
- endothelial cells
- high grade
- type diabetes
- locally advanced
- oxidative stress
- papillary thyroid
- stem cells
- squamous cell carcinoma
- computed tomography
- metabolic syndrome
- mesenchymal stem cells
- radiation therapy
- combination therapy
- bone marrow
- induced pluripotent stem cells
- deep learning