Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis.
Markus KielerLeona Sophia PrammerGerwin HellerMelanie HofmannSimon SpergerDominik HanetsederBirgit NiederreiterAndrea KomljenovicKristaps KlavinsThomas KöcherJulia Stefanie BrunnerIrena StanicLaura OberbichlerAna KorosecAndrea VogelMartina KerndlDominika HromadováLaszlo MusiejovskyAlexander HajtoAnja DobrijevicTina PiwonkaArvand HaschemiAnne MillerPhilippe GeorgelDarja Marolt PresenJohannes GrillariSilvia HayerJean-Philippe AugerGerhard KrönkeOmar SharifDaniel AletahaGernot SchabbauerStephan BlümlPublished in: Annals of the rheumatic diseases (2024)
In summary, we identify itaconate, generated as a result of the metabolic rewiring during osteoclast differentiation, as a previously unrecognised regulator of osteoblasts.
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