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Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion.

Yasunari FukudaSun-Hee KimMatias A BustosSung-Nam ChoJason RoszikJared K BurksHong KimDave S B HoonElizabeth A GrimmSuhendan Ekmekcioglu
Published in: Cancer research communications (2023)
Collagen is a predominant component of the extracellular matrix that may influence the tumor immune microenvironment for cancer progression. We present here that mPGES-1 has specific roles in regulating tumor immunity, associated with several collagen-related genes and propose that pharmacologic inhibition of mPGES-1 may hold therapeutic promise for improving immune checkpoint-based therapies.
Keyphrases
  • extracellular matrix
  • wound healing
  • tissue engineering
  • papillary thyroid
  • stem cells
  • young adults
  • artificial intelligence
  • skin cancer
  • basal cell carcinoma