Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion.
Yasunari FukudaSun-Hee KimMatias A BustosSung-Nam ChoJason RoszikJared K BurksHong KimDave S B HoonElizabeth A GrimmSuhendan EkmekciogluPublished in: Cancer research communications (2023)
Collagen is a predominant component of the extracellular matrix that may influence the tumor immune microenvironment for cancer progression. We present here that mPGES-1 has specific roles in regulating tumor immunity, associated with several collagen-related genes and propose that pharmacologic inhibition of mPGES-1 may hold therapeutic promise for improving immune checkpoint-based therapies.