Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides.

Zhao WuJoshua D LaffoonTrang T NguyenJacob D McAlpinKami L Hull

Published in: Angewandte Chemie (International ed. in English) (2016)

A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.

Keyphrases

hydrogen peroxide
room temperature
solid state
mass spectrometry
loop mediated isothermal amplification
electron transfer