Positive associations between cannabis and alcohol use polygenic risk scores and phenotypic opioid misuse among African-Americans.

Jill A RabinowitzJin JinSally I-Chun KuoAdrian I CamposMiguel E RenteríaAndrew S HuhnJohannes ThrulBeth A ReboussinKelly BenkeBenjamin DomingueNicholas S IalongoBrion S MaherDarlene KertesVanessa TroianiGeorge Uhl

Published in: PloS one (2022)

Our findings further elucidate the genetic contributions to misusing opioids by showing that the genetics of cannabis and alcohol consumption are associated with lifetime opioid misuse among young adults, though replication of our findings is needed.

Keyphrases

chronic pain
alcohol consumption
pain management
young adults
copy number
gene expression