Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia.
Lucia A A GianniniRuben G BoersEmma L van der EndeJackie M PoosLize C JiskootJoachim B BoersWilfred F J Van IJckenElise G DopperYolande A L PijnenburgHarro SeelaarLieke H MeeterJeroen G J van RooijWiep ScheperJoost H GribnauJohn Cornelis van SwietenPublished in: Annals of clinical and translational neurology (2024)
A distinctive methylation profile of cfDNA characterizes the presymptomatic stage of genetic FTD, and could reflect neuronal death in this stage.