Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway.
Naoki IwamotoShoichi FukuiAyuko TakataniToshimasa ShimizuMasataka UmedaAyako NishinoTakashi IgawaTomohiro KogaShin-Ya KawashiriKunihiro IchinoseMami TmaiHideki NakamuraTomoki OriguchiKo ChibaMakoto OsakiAstrid JüngelSteffen GayAtsushi KawakamiPublished in: Arthritis research & therapy (2018)
We identified miR-218 as a crucial inducer of the osteogenic differentiation of RA-FLS. MiR-218 modulates the osteogenic differentiation of RA-FLS through the ROBO1/DKK-1 axis. The induction of the osteogenic differentiation of proliferating RA-FLS through the provision of miR-218 into RA-FLS or by boosting the cellular reservoir of miR-218 might thus become a therapeutic strategy for RA.