Usefulness of central radiologic review in clinical trials of children with hepatoblastoma.

Osamu MiyazakiEiji OgumaMasanori NishikawaYutaka TanamiTakahiro Hosokawa Masahiro Kitami Hidekazu Aoki Shinya HattoriKen MotooriKenichiro WatanabeKohmei IdaTomoro HishikiMasayuki KitamuraKumiko NozawaTetsuya TakimotoEiso Hiyama

Published in: Pediatric radiology (2022)

In a clinical trial of hepatoblastoma, central review provided a more precise diagnosis than local site diagnoses with respect to severe PRETEXT stages III and IV cases and other cases including hepatic and portal vein invasion. The central review process appears to be effective and essential for improving the quality of clinical trials.

Keyphrases

clinical trial
phase ii
open label
young adults
phase iii
early onset