Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD.

Joselyn Rojas-QuinteroScott A OchsnerFelicia NewPrajan DivakarChen Xi YangTianshi David WuJerid RobinsonDarshan Shimoga ChandrashekarNicholas E BanovichIvan O RosasMaor SaulerFarrah KheradmandAmit GaggarCamilla MargaroliRaul San Jose EsteparNeil J McKennaFrancesca Polverino

Published in: American journal of respiratory and critical care medicine (2023)

An off-targeted B cell activation within LFs is associated with autoimmune-mediated emphysema pathogenesis.

Keyphrases

chronic obstructive pulmonary disease
lung function
pulmonary fibrosis
cystic fibrosis
single cell
air pollution
multiple sclerosis
idiopathic pulmonary fibrosis
cancer therapy
drug induced