Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV2 Infection.
Pushkala JayaramanMadhumitha RajagopalIshan ParanjpeLora LiharskaMayte Suárez-FariñasRyan C ThompsonDiane M Del ValleNoam D BeckmannWonsuk OhFaris F GulamaliJustin KauffmanEdgar G KozlovaSergio DellepianeGeorge Vasquez-RiosAkhil VaidJoy JiangAnnie ChenAnkit SakhujaSteven ChenEphraim KenigsbergJohn Cijiang HeSteven G CocaLili ChanEric SchadtMiram MeradSeunghee Kim-SchulzeSacha GnjaticEphraim L TsalikRaymond J LangleyAlexander W CharneyGirish Nitin NadkarniPublished in: medRxiv : the preprint server for health sciences (2023)
Peripheral transcriptomic findings in acute and long-term kidney dysfunction after hospitalization for SARS-CoV2 infection are unclear. We evaluated peripheral blood molecular signatures in AKI from COVID-19 (COVID-AKI) and their association with long-term kidney dysfunction using the largest hospitalized cohort with transcriptomic data. Analysis of 283 hospitalized patients of whom 37% had AKI, highlighted the contribution of mitochondrial dysfunction driven by endoplasmic reticulum stress in the acute stages. Subsequently, long-term kidney function decline exhibits significant associations with markers of cardiac structure and function and immune mediated dysregulation. There were similar biomolecular signatures in other inflammatory states, such as sepsis. This enhances the potential for repurposing and generalizability in therapeutic approaches.
Keyphrases
- acute kidney injury
- endoplasmic reticulum stress
- liver failure
- coronavirus disease
- sars cov
- respiratory failure
- oxidative stress
- single cell
- peripheral blood
- drug induced
- respiratory syndrome coronavirus
- induced apoptosis
- intensive care unit
- heart failure
- gene expression
- genome wide
- rna seq
- machine learning
- risk assessment
- dna methylation
- left ventricular
- atrial fibrillation
- extracorporeal membrane oxygenation