A Longitudinal Analysis of Early Lesion Growth in Presymptomatic Patients with Cerebral Adrenoleukodystrophy.
Eric James MallackGulce AskinStephanie I W van de StadtP A CarusoPatricia L MusolinoMarc EngelenSumit N NiogiFlorian S EichlerPublished in: AJNR. American journal of neuroradiology (2021)
Measuring the volumetric changes in newly developing cerebral lesions across time can distinguish cerebral adrenoleukodystrophy phenotypes before symptom onset. When factored into the overall clinical presentation of a patient with a new brain lesion, quantitative MR imaging-based lesion volumetry may aid in the accurate prediction of patients eligible for therapy.
Keyphrases
- subarachnoid hemorrhage
- end stage renal disease
- cerebral ischemia
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high resolution
- brain injury
- prognostic factors
- case report
- stem cells
- patient reported
- cerebral blood flow
- blood brain barrier
- magnetic resonance
- patient reported outcomes
- cell therapy
- mass spectrometry