Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE.

Faruk RamadaniN UptonP HobsonY-C ChanD MzinzaH BowenC KerridgeB J SuttonD J FearH J Gould

Published in: Allergy (2015)

This study shows that the maturation state of tonsil B cells determines their capacity to undergo class switching to IgE ex vivo, with the GC-derived B cells yielding the highest percentage of IgE(+) cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway