GHSR-1 agonist sensitizes rat colonic intrinsic and extrinsic neurons to exendin-4: A role in the manifestation of postprandial gastrointestinal symptoms in irritable bowel syndrome?

Maria M BuckleyRebecca O'BrienJulliette M BuckleyDervla O'Malley

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

These findings support a temporal interaction between ghrelin and GLP-1, where the preprandial peak in ghrelin may temporarily sensitize colonic intrinsic and extrinsic neurons to the neurostimulatory actions of GLP-1. While the sensitizing effects of the GHSR-1 agonist were identified in both rat strains, in the rat model of IBS, underlying contractile activity was aberrant.

Keyphrases

irritable bowel syndrome
spinal cord
oxidative stress
ulcerative colitis
escherichia coli
skeletal muscle
type diabetes
metabolic syndrome
sleep quality