HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway.

Lumin WangYi GaoXiaoge ZhaoChen GuoXiaofei WangYang YangCong HanLing-Yu ZhaoYannan QinLiying LiuChen HuangWenjing Wang

Published in: Cell proliferation (2020)

Therefore, HOXD3, a target of YY1, facilitates HCC progression via activation of the ERK1/2 signalling by promoting ITGA2. This finding provides a new whole way to HCC therapy by serving YY1-HOXD3-ITGA2 regulatory axis as a potential therapeutic target for HCC therapy.

Keyphrases

signaling pathway
cell proliferation
transcription factor
stem cells
pi k akt
risk assessment
human health
climate change
mesenchymal stem cells