Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine.
Lionel MauriziVanessa BellatMathieu MoreauEmmanuel De MaistreJulien BoudonLaure DumontFranck DenatDavid VandrouxNadine MillotPublished in: RSC advances (2022)
Nanoparticles capable of mimicking natural tissues represent a major technological advancement in regenerative medicine. In this pilot study, the development of a new nanohybrid composed of titanate nanoribbons to mimic the extracellular matrix is reported. During the first phase, nanoribbons were synthesized by hydrothermal treatment. Subsequently, titanate nanoribbons were functionalized by heterobifunctional polyethylene-glycol (PEG) to graft type I collagen on their surface. Biological properties of this new nanobiohybrid such as cytotoxicity to cardiac cells and platelet aggregation ability were evaluated. The so-formed nanobiohybrid permits cellular adhesion and proliferation favoring fine cardiac tissue healing and regeneration.
Keyphrases
- extracellular matrix
- induced apoptosis
- left ventricular
- stem cells
- signaling pathway
- cell cycle arrest
- air pollution
- drug delivery
- wound healing
- quantum dots
- oxidative stress
- heart failure
- endoplasmic reticulum stress
- cell death
- staphylococcus aureus
- gold nanoparticles
- tissue engineering
- anaerobic digestion
- cell proliferation
- combination therapy
- risk assessment
- replacement therapy
- sewage sludge
- cell migration