Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved.

Fangfang XiaZhousheng JinTingting LinXixi CaiLinmin PanShi WangYaoyao CaiHongfei Chen

Published in: BMC pharmacology & toxicology (2019)

Dexmedetomidine could delay the occurrence of bupivacaine-induced arrhythmia and asystole in the isolated rat hearts, but the alpha 2 adrenoceptors were not involved in this process.

Keyphrases

oxidative stress
pain management
cardiac surgery
postoperative pain
diabetic rats
high glucose
risk assessment
drug induced
endothelial cells
chronic pain