Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition.
Julie BonnereauTristan CourauNicolas AsesioDelphine SalfatiFatiha BouhidelHélène CorteSarah HamoudiNassim HammoudiJulie LavoléJustine Vivier-ChicoteauVictor ChardinyLeon MaggioriMathieu BleryRomain RemarkCécile BonnafousPierre CattanAntoine ToubertPurnima BhatMatthieu AllezThomas AparicioLionel Le BourhisPublished in: Gut (2022)
In CRC, CD39 is strongly expressed on tumour infiltrating lymphocytes and its inhibition represents a promising therapeutic strategy for treating patients.