Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.

Arno C HesselsAbraham RutgersJan Stephan F SandersCoen A Stegeman

Published in: PloS one (2018)

TPMT genotype and activity were not independent predictors of relapse, and could not predict leukopenia or other adverse effects from azathioprine. Leukocyte counts after cyclophosphamide induction were related to both outcomes, implying a greater influence of cyclophosphamide response compared to azathioprine and TPMT in AAV patients.

Keyphrases

low dose
end stage renal disease
high dose
ejection fraction
newly diagnosed
prognostic factors
type diabetes
metabolic syndrome