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Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression.

Yao LiYan ZhangXufang WangQian YangXuanxuan ZhouJunsheng WuXu YangYani ZhaoRui LinYanhua XieJiani YuanXiaohui ZhengSi-Wang Wang
Published in: Cancer cell international (2021)
Our research indicated that bufalin can cause Annexin A2 and DRP1 oligomerization on the surface of mitochondria and disrupt the mitochondrial division/fusion balance to induce U251 cell apoptosis.
Keyphrases
  • oxidative stress
  • cell death
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell proliferation
  • reactive oxygen species
  • endoplasmic reticulum
  • signaling pathway