Benzodiazepine and zolpidem prescriptions during autologous stem cell transplantation.
Rahul BanerjeeAnn A LazarLisa DunnJennifer KnocheMimi LoShagun AroraSandy W WongJeffrey L WolfThomas G MartinAnand DhruvaNina ShahPublished in: EJHaem (2021)
Multiple myeloma patients undergoing autologous stem cell transplantation (ASCT) may receive benzodiazepine or zolpidem-class (B/Z) medications despite their risks in older patients. Of 205 myeloma patients (36% aged 65+) who underwent ASCT at our institution between 2017 and 2018, we found that B/Z prescription rates for anxiety/insomnia rose significantly from 26% before ASCT to 38% at discharge and 39% at Day +100. B/Z initiation while hospitalized was a strong predictor of B/Z persistence at Day +100. Our findings highlight the role of these potentially inappropriate medications during hospitalizations for ASCT, a period where nonpharmacologic strategies for managing anxiety/insomnia may be feasible.
Keyphrases
- stem cell transplantation
- high dose
- multiple myeloma
- sleep quality
- end stage renal disease
- newly diagnosed
- patients undergoing
- ejection fraction
- bone marrow
- chronic kidney disease
- cell therapy
- peritoneal dialysis
- low dose
- stem cells
- risk assessment
- physical activity
- patient reported outcomes
- mesenchymal stem cells
- climate change