Immunomodulatory effect of IL-1RA in LPS-activated macrophage/dental pulp stem cells co-culture.

Vellore Kannan GopinathMohammad G MohammadSoumya Sheela

Published in: International endodontic journal (2022)

Blocking the IL-1 receptor in hDPSCs and macrophage (M0, M1, M2) co-cultures activated with LPS resulted in downregulation of inflammatory cytokines IL-1β and TNF-α. These findings highlight the immunomodulatory effect of IL-1RA in inflammatory conditions of dental pulp infections.

Keyphrases

stem cells
rheumatoid arthritis
inflammatory response
adipose tissue
anti inflammatory
oxidative stress
signaling pathway
bone marrow
mesenchymal stem cells
binding protein