Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats.
Jan A MennigenLindsay M ThompsonMandee BellMarlen Tellez SantosAndrea C GorePublished in: Environmental health : a global access science source (2018)
PCBs caused body weight and hormonal effects in rats that were not observed in the directly exposed F1 offspring, but emerged in F2 and F3 generations. Furthermore, most effects were in the maternal lineage; this may relate to the timing of exposure of the F1 fetuses at E16 and 18, when germline (the future F2 generation) epigenetic changes diverge in the sexes. These results showing transgenerational effects of EDCs have implications for humans, as we are now in the 3rd generation since the Chemical Revolution of the mid-twentieth century, and even banned chemicals such as PCBs have a persistent imprint on the health of our descendants.
Keyphrases
- body weight
- healthcare
- public health
- gene expression
- dna methylation
- high fat diet
- risk assessment
- single cell
- current status
- health information
- adipose tissue
- gestational age
- polycyclic aromatic hydrocarbons
- polycystic ovary syndrome
- insulin resistance
- oxidative stress
- skeletal muscle
- social media
- preterm birth
- human health
- weight loss