Revealing biophysical properties of KfrA-type proteins as a novel class of cytoskeletal, coiled-coil plasmid-encoded proteins.

Malgorzata AdamczykE LewickaR SzatkowskaH NieznanskaJ LudwiczakM JasińskiS Dunin-HorkawiczE SitkiewiczB SwiderskaG GochG Jagura-Burdzy

Published in: BMC microbiology (2021)

KfrAR751 and KfrARA3 are structural homologues. We postulate that KfrA type proteins have moonlighting activity. They not only act as transcriptional auto-regulators but form cytoskeletal structures, which might facilitate plasmid DNA delivery and positioning in the cells before cell division, involving thermal energy.

Keyphrases

cell death
cell cycle arrest
escherichia coli
crispr cas
induced apoptosis
transcription factor
single cell
high resolution
stem cells
cell free
circulating tumor
mass spectrometry
signaling pathway