Calcium chelation: a novel approach to reduce cryopreservation-induced damage to frozen platelets.

Lauren WatersMatthew P PadulaDenese C MarksLacey Johnson

Published in: Transfusion (2020)

This study demonstrates that calcium plays a crucial role in mediating cryopreservation-induced damage to frozen platelets. The addition of the calcium chelator, BAPTA-AM, prior to cryopreservation reduces this damage.

Keyphrases

oxidative stress
diabetic rats
high glucose
drug induced
endothelial cells