Diabetes medications and associations with Covid-19 outcomes in the N3C database: A national retrospective cohort study.
Carolyn T BramanteSteven G JohnsonVictor GarciaMichael D EvansJeremy HarperKenneth J WilkinsJared D HulingHemalkumar MehtaG Caleb AlexanderJena Shaw TronieriStephenie HongAnna KahkoskaJoy AlamgirFarrukh KoraishyKatrina M HartmanKaifeng YangTrine J AbrahamsenTil StürmerJohn B Busenull nullPublished in: PloS one (2022)
There were clinically significant associations between metformin use and less severe COVID-19 compared to SU, but not compared to DPP4i. New-user studies and randomized trials are needed to assess early outpatient treatment and post-exposure prophylaxis with therapeutics that are safe in adults, children, pregnancy and available worldwide.