CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling.

Junxin ChenGang LiuYizheng WuJianjun MaHongfei WuZiang XieShuai ChenYute YangShengyu WangPanyang ShenYifan FangShunwu FanShuying ShenXiang-Qian Fang

Published in: Molecular cancer (2019)

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to promote chromatin remodeling and thus enhances the transcriptional activity of β-catenin/LEF1 complex, which indicates that circMYO10 may be a potential therapeutic target for osteosarcoma treatment.

Keyphrases

gene expression
transcription factor
epithelial mesenchymal transition
dna damage
cell proliferation
genome wide
dna methylation
heat shock
risk assessment
combination therapy
human health
replacement therapy