Retreatment decision for hepatitis B flare in HBeAg negative Chronic Hepatitis B.

We read with great interest the review by Liaw et al which has described an interesting area determining the timing of retreatment of flare after stopping of nucleos(t)ide analogues (NA) in hepatitis B e Antigen (HBeAg) chronic hepatitis B(CHB) by using quantitative hepatitis B surface antigen (qHBsAg) and alanine transaminase (ALT) kinetics.