Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Down-Regulated PI3K/AKT Signaling in Bone Tissues.
Xiaoye DuanQi PanLixin GuoPublished in: Nature and science of sleep (2022)
These results suggest that CSD can significantly impaire bone health, and it may exert these effects in part by suppressing bone formation and osteoblast differentiation, and inactivating the PI3K/AKT signaling pathway.
Keyphrases
- pi k akt
- signaling pathway
- bone regeneration
- bone mineral density
- cell cycle arrest
- cell proliferation
- healthcare
- soft tissue
- public health
- gene expression
- bone loss
- epithelial mesenchymal transition
- induced apoptosis
- mental health
- postmenopausal women
- physical activity
- sleep quality
- health information
- oxidative stress
- risk assessment
- cell death
- social media
- drug induced