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Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC.

Francesco PadovaniBenedikt MairhörmannPascal Falter-BraunJette LengefeldKurt M Schmoller
Published in: BMC biology (2022)
Cell-ACDC provides a framework for the application of state-of-the-art deep learning models to the analysis of live cell imaging data without programming knowledge. Furthermore, it allows for visualization and correction of segmentation and tracking errors as well as annotation of cell cycle stages. We embedded several smart algorithms that make the correction and annotation process fast and intuitive. Finally, the open-source and modularized nature of Cell-ACDC will enable simple and fast integration of new deep learning-based and traditional methods for cell segmentation, tracking, and downstream image analysis. Source code: https://github.com/SchmollerLab/Cell_ACDC.
Keyphrases
  • deep learning
  • cell cycle
  • single cell
  • cell therapy
  • convolutional neural network
  • cell proliferation
  • machine learning
  • healthcare
  • high resolution
  • electronic health record
  • rna seq
  • fluorescence imaging