Therapeutic Drug Monitoring of Newer Antiepileptic Drugs: A Randomized Trial for Dosage Adjustment.

Irene Aícua-RapúnPascal AndréAndrea O RossettiPhilippe RyvlinAndreas F HottingerLaurent A DecosterdThierry BuclinJan Novy

Published in: Annals of neurology (2019)

This study provides class A evidence that systematic drug level monitoring of newer generation AEDs does not bring tangible benefits in the management of patients with epilepsy. Poor correlation between clinical effects and drug levels likely accounts for this finding. However, TDM is useful in several situations, such as pregnancy, as well as when there are compliance issues. ANN NEUROL 2020;87:22-29.

Keyphrases

drug induced
emergency department
pregnant women