Post-Ebola Syndrome Presents With Multiple Overlapping Symptom Clusters: Evidence From an Ongoing Cohort Study in Eastern Sierra Leone.
Nell G BondDonald S GrantSarah T HimmelfarbEmily J EngelFoday Al-HasanMichael GbakieFatima KamaraLansana KannehIbrahim MustaphaAdaora OkoliWilliam A FischerDavid WohlRobert F GarryRobert SamuelsJeffrey G ShafferJohn S SchieffelinPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
This study presents an in-depth characterization of post-Ebola syndrome in Sierra Leonean survivors >2.5 years after disease. The interrelationship between symptom clusters indicates that post-Ebola syndrome is a heterogeneous disease. The distinct musculoskeletal and non-musculoskeletal phenotypes identified likely require targeted therapies to optimize long-term treatment for EVD survivors.