Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line.

Alper Ertuğrul Dilek Ozkaya Mustafa Nazıroğlu

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2023)

influx and retinal oxidative toxicity were induced in an ARPE19 cell line through the stimulation of TRPM2, although they were attenuated by treatment with CRC. Hence, CRC may be a potential therapeutic antioxidant for TRPM2 activation and HCQ treatment-induced retinal oxidative injury and apoptosis.

Keyphrases

oxidative stress
diabetic rats
optical coherence tomography
high glucose
dna damage
ischemia reperfusion injury
induced apoptosis
signaling pathway
cell proliferation
endothelial cells